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Cheyenne ArcServe has a Notes agent which lets it back up open databases. The agent requires a "work area" of the size of your largest Notes database because it creates a replica of a database into a separate directory before backing up that database.
IBM's ADSM will back up open files and can back up databases incrementally.
Veritas's Backup Exec with the Open File Option (they also have a Domino agent).
Unix's tar (and ports of it to other platforms like NT and OS/2) will back up open files.
Notes R3 Notes R4 Notes/Domino 4.5 Notes/Domino 4.6 Notes/Domino R5